ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that causes multi-systemic manifestations identified as coronavirus disease 2019 (COVID-19). Respiratory tract symptoms are the most commonly seen in infected patients with COVID-19. Hypercoagulability state is the most common coagulopathy disorder associated with critically ill COVID-19 patients. Several inflammatory and coagulation factors such as D-dimers and fibrinogen correlate with the degree of pro-thrombotic state and burden of the disease. We describe a case of a 51-year-old man who presented with respiratory pneumonia and concomitant severe bilateral arterial thrombosis followed by right above knee amputation.
ABSTRACT
BACKGROUND: Preexisting alteration of the immune system by factors including older age, cardiovascular diseases, morbid obesity, diabetes, and chronic obstructive pulmonary disease (COPD) have detrimental effects on SARS-CoV-2 patients. Literature regarding SARS-CoV-2/human immunodeficiency virus (HIV) is still developing. MATERIALS AND METHODS: We reviewed the existing literature pertaining to SARS-CoV-2/HIV coinfection systematically. Research records' characteristics and patients' clinical data were collected. RESULTS: Seven research records were included, of which three were case series and four were case reports, reporting a total of 16 cases. There was one case of death, whereas (15/16) patients were discharged home. Majority of patients developed consistent clinical presentation of SARS-CoV-2. All patients had initial positive RT-PCR results, and four cases had HIV-related lymphopenia. CONCLUSION: Although the current literature is still growing to increase our understanding of SARS-CoV-2/HIV coinfection, people living with HIV should adhere to the guidelines of healthy behavior and practice during this pandemic.